Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are
small (104 amino acids) and have a striking relationship to the acute phase response with …

Spatial barcoding technologies have the potential to reveal histological details of
transcriptomic profiles; however, they are currently limited by their low resolution. Here, we …

Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and
help to coordinate immune responses. Here we report profiling of 53,193 individual …

Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from
pathogenic microbes but are also prominent effectors of inflammation and autoimmune …

The liver is the most common site of metastatic disease. Although this metastatic tropism
may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also …

RORγt+ Th17 cells are important for mucosal defenses but also contribute to autoimmune
disease. They accumulate in the intestine in response to microbiota and produce IL-17 …

Inducible expression of serum amyloid A (SAA) is a hallmark of the acute-phase response,
which is a conserved reaction of vertebrates to environmental challenges such as tissue …

Oropharyngeal candidiasis (OPC; thrush) is an opportunistic infection caused by the
commensal fungus Candida albicans. Interleukin-17 (IL-17) and IL-22 are cytokines …

Serum amyloid A (SAA) subtypes 1–3 are well-described acute phase reactants that are
elevated in acute inflammatory conditions such as infection, tissue injury, and trauma, while …