Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Pancreatic islet transplantation in humans: recent progress and future directions
MR Rickels, RP Robertson - Endocrine reviews, 2019 - academic.oup.com
Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
[HTML][HTML] A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
[HTML][HTML] SARS-CoV-2 infection induces beta cell transdifferentiation
Recent clinical data have suggested a correlation between coronavirus disease 2019
(COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in …
(COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in …
[HTML][HTML] T cell-mediated beta cell destruction: autoimmunity and alloimmunity in the context of type 1 diabetes
AL Burrack, T Martinov, BT Fife - Frontiers in endocrinology, 2017 - frontiersin.org
Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …
immune system. Despite improvements in insulin analogs and continuous blood glucose …
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes
Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …
Advances in β-cell replacement therapy for the treatment of type 1 diabetes
The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …
reduce disease complications. For some patients, technological approaches to insulin …
[HTML][HTML] Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation
Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets
in sufficient quantities. Cryopreservation could solve islet supply chain challenges by …
in sufficient quantities. Cryopreservation could solve islet supply chain challenges by …
Organoid microphysiological system preserves pancreatic islet function within 3D matrix
Three-dimensional (3D) multicellular organoids recapitulate the native complexities of
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
human tissue better than traditional cellular monolayers. As organoids are insufficiently …
The human islet: mini-organ with mega-impact
JT Walker, DC Saunders, M Brissova… - Endocrine …, 2021 - academic.oup.com
This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …
development, function, and dysfunction. After providing a historical timeline of key …