Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …

Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy
comparing to monotherapy. The underlying mechanisms responsible for the synergistic …

An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The
substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a …

Abstract Objective Targeting deubiquitinases (DUBs) has emerged as a promising avenue
for anticancer drug development. However, the effect and mechanism of pan-DUB inhibitor …

Background Triple-negative breast cancer (TNBC) remains the most challenging subtype of
breast cancer and lacks definite treatment targets. Aerobic glycolysis is a hallmark of …

Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial
Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role …

Protein homeostasis is predominantly governed through post-translational modification
(PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast …

Abstract Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that
regulates various physiological functions by removing ubiquitin chains from target proteins …

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or
cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately …