Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
IL-6 as a keystone cytokine in health and disease
CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …
of the immune system and often displays hormone-like characteristics that affect homeostatic …
P2X7 interactions and signaling–making head or tail of it
R Kopp, A Krautloher, A Ramírez-Fernández… - Frontiers in Molecular …, 2019 - frontiersin.org
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
[HTML][HTML] The shedding protease ADAM17: Physiology and pathophysiology
F Zunke, S Rose-John - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
The disintegrin metalloprotease ADAM17 has been a matter of intense studies aiming to
unravel structure, function and regulation of protease expression, maturation and activity. In …
unravel structure, function and regulation of protease expression, maturation and activity. In …
Interleukin-6 and its receptors: a highly regulated and dynamic system
J Wolf, S Rose-John, C Garbers - Cytokine, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …
inflammatory properties. Although only small amounts in the picogram range can be …
The two-faced cytokine IL-6 in host defense and diseases
M Narazaki, T Kishimoto - International journal of molecular sciences, 2018 - mdpi.com
Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to
the whole body via the blood stream, promptly activating the host defense system to perform …
the whole body via the blood stream, promptly activating the host defense system to perform …
Therapeutic targeting of IL-6 trans-signaling
S Rose-John - Cytokine, 2021 - Elsevier
Abstract Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity,
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …
Metalloproteinases and their natural inhibitors in inflammation and immunity
R Khokha, A Murthy, A Weiss - Nature Reviews Immunology, 2013 - nature.com
Over the past 50 years, steady growth in the field of metalloproteinase biology has shown
that the degradation of extracellular matrix components represents only a fraction of the …
that the degradation of extracellular matrix components represents only a fraction of the …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To
determine critical genes regulated by hypoxia that promote invasion and metastasis, we …
determine critical genes regulated by hypoxia that promote invasion and metastasis, we …