[HTML][HTML] Cough hypersensitivity and chronic cough

KF Chung, L McGarvey, WJ Song, AB Chang… - Nature Reviews …, 2022 - nature.com
Chronic cough is globally prevalent across all age groups. This disorder is challenging to
treat because many pulmonary and extrapulmonary conditions can present with chronic …

Adult‐onset eosinophilic airway diseases

K Asano, S Ueki, M Tamari, Y Imoto, S Fujieda… - Allergy, 2020 - Wiley Online Library
Eosinophilic airway inflammation is one of the cardinal features of allergic airway diseases
such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated …

Eosinophil extracellular traps drive asthma progression through neuro-immune signals

Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li… - Nature Cell …, 2021 - nature.com
Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …

[HTML][HTML] A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

A Balestrini, V Joseph, M Dourado, RM Reese… - Journal of Experimental …, 2021 - rupress.org
Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …

Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

AC Bohrer, E Castro, Z Hu, ATL Queiroz… - Journal of Experimental …, 2021 - rupress.org
Host resistance to Mycobacterium tuberculos is (Mtb) infection requires the activities of
multiple leukocyte subsets, yet the roles of the different innate effector cells during …

Identification of lung innervating sensory neurons and their target specificity

Y Su, J Barr, A Jaquish, J Xu… - American Journal of …, 2022 - journals.physiology.org
Known as the gas exchange organ, the lung is also critical for responding to the aerosol
environment in part through interaction with the nervous system. The diversity and specificity …

Eosinophils regulate intra-adipose axonal plasticity

X Meng, X Qian, X Ding, W Wang… - Proceedings of the …, 2022 - National Acad Sciences
Sympathetic innervation regulates energy balance, and the nerve density in the adipose
tissues changes under various metabolic states, resulting in altered neuronal control and …

[HTML][HTML] Airway innervation and plasticity in asthma

LEM Kistemaker, YS Prakash - Physiology, 2019 - journals.physiology.org
Airway nerves represent a mechanistically and therapeutically important aspect that requires
better highlighting in the context of diseases such as asthma. Altered structure and function …

[HTML][HTML] Neuroimmune pathophysiology in asthma

GF Pavón-Romero, NH Serrano-Pérez… - Frontiers in Cell and …, 2021 - frontiersin.org
Asthma is a chronic inflammation of lower airway disease, characterized by bronchial
hyperresponsiveness. Type I hypersensitivity underlies all atopic diseases including allergic …

[HTML][HTML] Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma

RD Britt Jr, A Ruwanpathirana, ML Ford… - International journal of …, 2023 - mdpi.com
Asthma is a heterogenous chronic inflammatory lung disease with endotypes that manifest
different immune system profiles, severity, and responses to current therapies. Regardless of …