Dietary restriction (DR) has long been viewed as the most robust nongenetic means to
extend lifespan and healthspan. Many aging-associated mechanisms are nutrient …

Hypothalamic dysfunction has emerged as an important mechanism involved in the
development of obesity and its comorbidities, as well as in the process of ageing and age …

Human DNA-methylation data have been used to develop highly accurate biomarkers of
aging (" epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for …

Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

Aging is characterized by autophagy impairment that contributes to age-related disease
aggravation. Moreover, it was described that the hypothalamus is a critical brain area for …

Caloric restriction is an anti-aging intervention known to extend lifespan in several
experimental models, at least in part, by stimulating autophagy. Caloric restriction increases …

With our aging society, more people hope for a long and healthy life. In recent years,
researchers have focused on healthy longevity factors. In particular, calorie restriction delays …

Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan
determination. In this review, we critically discuss age-related changes in NPY levels in the …

Reduced appetite or anorexia substantially deteriorates quality of life in various diseases
including cancer, depression and heart failure. Furthermore, reduced appetite may stand …

This review focuses on mechanisms of calorie restriction (CR), particularly the growth
hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal …