Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets,
Kupffer cells and other immune cells, and binds to various ligands including the mucin-like …

Abstract The glycoprotein VI (GPVI)-Fc receptor γ (FcRγ) chain is the major platelet signaling
receptor for collagen. Paradoxically, in a FeCl3 injury model, occlusion, but not initiation of …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with
high morbidity and mortality. Excessive neutrophil infiltration into the pulmonary airspace is …

Background The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones
and neutrophil proteases from neutrophils, was first demonstrated as a host defence against …

A state-of-the-art lecture titled “novel mechanisms of thrombo-inflammation during infection”
was presented at the ISTH Congress in 2022. Platelet, neutrophil, and endothelial cell …

Platelet collagen receptor glycoprotein VI (GPVI) and podoplanin receptor C-type lectin-like
receptor 2 (CLEC2) are receptors implicated in platelet activation that both signal via an …

Fucoidan—a marine natural active polysaccharide derived from brown algae with a variety
of medicinal activities and low toxicity—has been used as clinical drug for renal diseases for …

Much interest surrounds the receptors α2β1 and glycoprotein VI (GPVI) whose synchronized
action mediates the attachment and activation of platelets on collagen, essential for …

The platelet C-type lectin-like receptor CLEC-2 drives inflammation-driven venous
thrombosis in mouse models of thrombo-inflammatory disease with a minimal effect on …