Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However,
excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species …

Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

An estimated 58 million people have survived tuberculosis since 2000, yet many of them will
suffer from post-tuberculosis lung disease (PTLD). PTLD results from a complex interplay …

Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors
determining disease progression are unclear. Transcriptional signatures associated with …