Epigenetic mechanisms of immune remodeling in sepsis: targeting histone modification

D Wu, Y Shi, H Zhang, C Miao - Cell death & disease, 2023 - nature.com
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Role of immuno-inflammatory signals in liver ischemia-reperfusion injury

C Kaltenmeier, R Wang, B Popp, D Geller, S Tohme… - Cells, 2022 - mdpi.com
Ischemia reperfusion injury (IRI) is a major obstacle in liver resection and liver
transplantation. The initial step of IRI is mediated through ischemia which promotes the …

Immunomodulatory biomaterials against bacterial infections: Progress, challenges, and future perspectives

S Zhang, H Yang, M Wang, D Mantovani, K Yang… - The Innovation, 2023 - cell.com
Bacterial infectious diseases are one of the leading causes of death worldwide. Even with
the use of multiple antibiotic treatment strategies, 4.95 million people died from drug …

Histones: The critical players in innate immunity

X Li, Y Ye, K Peng, Z Zeng, L Chen, Y Zeng - Frontiers in immunology, 2022 - frontiersin.org
The highly conserved histones in different species seem to represent a very ancient and
universal innate host defense system against microorganisms in the biological world …

The role of neutrophils in rheumatic disease-associated vascular inflammation

L Wang, R Luqmani, IA Udalova - Nature Reviews Rheumatology, 2022 - nature.com
Vascular pathologies underpin and intertwine autoimmune rheumatic diseases and
cardiovascular conditions, and atherosclerosis is increasingly recognized as the leading …

Skin wound healing: of players, patterns, and processes

H Sorg, CGG Sorg - European Surgical Research, 2023 - karger.com
Background: Wound healing of the skin is a very complex biological activity. For a better
understanding, an attempt is made to describe and subdivide the different players (cell types …

Neutrophil extracellular traps in cancer therapy resistance

MH Shahzad, L Feng, X Su, A Brassard… - Cancers, 2022 - mdpi.com
Simple Summary Neutrophils are a type of white blood cell that also play a role in cancer.
They have been shown to influence various aspects of the disease, including resistance to …

Edaravone Dexborneol Downregulates Neutrophil Extracellular Trap Expression and Ameliorates Blood‐Brain Barrier Permeability in Acute Ischemic Stroke

Y Huang, X Zhang, C Zhang, W Xu, W Li… - Mediators of …, 2022 - Wiley Online Library
Background. Our previous work has shown that inflammatory processes play a detrimental
role in the pathophysiology of acute ischemic stroke (AIS). Neutrophil extracellular traps …

Role and therapeutic targeting strategies of neutrophil extracellular traps in inflammation

X Li, S Xiao, N Filipczak, SSK Yalamarty… - International Journal …, 2023 - Taylor & Francis
Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …

Application of regulatory cell death in cancer: based on targeted therapy and immunotherapy

X Qi, Q Li, X Che, Q Wang, G Wu - Frontiers in immunology, 2022 - frontiersin.org
The development of cancer treatment methods is constantly changing. For common cancers,
our treatment methods are still based on conventional treatment methods, such as …