The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

Initiation of translation on eukaryotic mRNAs generally follows the scanning mechanism,
wherein a preinitiation complex (PIC) assembled on the small (40S) ribosomal subunit and …

A key step in translational initiation is the recruitment of the 43 S preinitiation complex by the
cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5′ end of messenger …

Protein synthesis is mediated via numerous molecules including the ribosome, mRNA,
tRNAs, as well as translation initiation, elongation and release factors. Some of these factors …

Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the
5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation …

Ribosomes translate RNA into proteins. The protein synthesis inhibitor cycloheximide (CHX)
is widely used to inhibit eukaryotic ribosomes engaged in translation elongation. However …

Specific individual subunits of eIF3 are elevated or reduced in numerous human tumors, and
their ectopic overexpression in immortal cells can result in malignant transformation. The …

Translation in eukaryotes is highly regulated during initiation, a process impacted by
numerous readouts of a cell's state. There are many cases in which cellular messenger …

The 12-subunit mammalian eIF3 is the largest and most complex translation initiation factor
and has been implicated in numerous steps of translation initiation, termination and …

The multi-subunit eukaryotic translation initiation factor eIF3 is thought to assist in the
recruitment of ribosomes to mRNA. The expression of eIF3 subunits is frequently disrupted …