Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

In 2012, an international consensus paper reported that medulloblastoma comprises four
molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated with distinct …

Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB
risk stratification, which may aid therapeutic decision making, family counseling, and …

Background Disease relapse occurs in around 30% of children with medulloblastoma, and
is almost universally fatal. We aimed to establish whether the clinical and molecular …

Background Most children with medulloblastoma fall within the standard-risk clinical disease
group defined by absence of high-risk features (metastatic disease, large-cell/anaplastic …

Abstract Group 4 tumours (MBGrp4) represent the majority of non-WNT/non-SHH
medulloblastomas. Their clinical course is poorly predicted by current risk-factors. MBGrp4 …

Centromeric α-satellite repeats represent∼ 6% of the human genome, but their length and
repetitive nature make sequencing and analysis of those regions challenging. However …

Advances in molecular diagnostics have led to improved stratification and targeted
interventions in the treatment of children with brain tumors. This has necessitated complex …