The omniscient placenta: metabolic and epigenetic regulation of fetal programming

BM Nugent, TL Bale - Frontiers in neuroendocrinology, 2015 - Elsevier
Fetal development could be considered a sensitive period wherein exogenous insults and
changes to the maternal milieu can have long-term impacts on developmental programming …

Environmental metal exposure, neurodevelopment, and the role of iron status: a review

S Schildroth, K Kordas, JA Bauer, RO Wright… - Current Environmental …, 2022 - Springer
Abstract Purpose of Review Exposure to environmental metals, like lead (Pb), manganese
(Mn), and methylmercury (Me-Hg), has consistently been implicated in neurodevelopmental …

The impact of cumulative pain/stress on neurobehavioral development of preterm infants in the NICU

X Cong, J Wu, D Vittner, W Xu, N Hussain… - Early human …, 2017 - Elsevier
Background Vulnerable preterm infants experience repeated and prolonged pain/stress
stimulation during a critical period in their development while in the neonatal intensive care …

Analysis of neonatal neurobehavior and developmental outcomes among preterm infants

EC McGowan, JA Hofheimer, TM O'Shea… - JAMA Network …, 2022 - jamanetwork.com
Importance The ability to identify poor outcomes and treatable risk factors among very
preterm infants remains challenging; improving early risk detection and intervention targets …

A pilot study demonstrating the impact of the supporting and enhancing NICU sensory experiences (SENSE) program on the mother and infant

R Pineda, M Wallendorf, J Smith - Early human development, 2020 - Elsevier
Aim To explore differences in maternal mental health and infant neurobehavioral outcome
among infants who received and did not receive the Supporting and Enhancing NICU …

Early intervention programmes for infants at high risk of atypical neurodevelopmental outcome

B Hutchon, D Gibbs, P Harniess, S Jary… - … Medicine & Child …, 2019 - Wiley Online Library
The purpose of this review is to present a new framework, EI SMART (early intervention:
sensorimotor development, attention and regulation, relationships, and therapist support) for …

Randomized clinical trial investigating the effect of consistent, developmentally-appropriate, and evidence-based multisensory exposures in the NICU

R Pineda, J Smith, J Roussin, M Wallendorf… - Journal of …, 2021 - nature.com
Objective Evaluate the effect of a manualized multisensory program, applied across NICU
hospitalization, on infant and parent outcomes. Study design Seventy parent-infant dyads …

Maternal smoking during pregnancy and infant stress response: test of a prenatal programming hypothesis

LR Stroud, GD Papandonatos, D Rodriguez… - …, 2014 - Elsevier
Background Maternal smoking during pregnancy (MSDP) is associated with early and long-
term neurobehavioral deficits; however mechanisms remain unknown. We tested the …

Regions of variable DNA methylation in human placenta associated with newborn neurobehavior

AG Paquette, EA Houseman, BB Green, C Lesseur… - Epigenetics, 2016 - Taylor & Francis
The placenta regulates the in utero environment and functionally impacts fetal development.
Candidate gene studies identified variation in placental DNA methylation is associated with …

Placental FKBP5 Genetic and Epigenetic Variation Is Associated with Infant Neurobehavioral Outcomes in the RICHS Cohort

AG Paquette, BM Lester, DC Koestler, C Lesseur… - PloS one, 2014 - journals.plos.org
Adverse maternal environments can lead to increased fetal exposure to maternal cortisol,
which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol …