Structure and Function of Dynein's Non-Catalytic Subunits
L Rao, A Gennerich - Cells, 2024 - mdpi.com
Dynein, an ancient microtubule-based motor protein, performs diverse cellular functions in
nearly all eukaryotic cells, with the exception of land plants. It has evolved into three …
nearly all eukaryotic cells, with the exception of land plants. It has evolved into three …
[HTML][HTML] Number of kinesins engaged in axonal cargo transport: A novel biomarker for neurological disorders
K Hayashi, K Sasaki - Neuroscience Research, 2023 - Elsevier
Kinesin motor proteins play crucial roles in anterograde transport of cargo vesicles in
neurons, moving them along axons from the cell body towards the synaptic region. Not only …
neurons, moving them along axons from the cell body towards the synaptic region. Not only …
Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning
H Vitet, J Bruyère, H Xu, C Séris, J Brocard, YS Abada… - Elife, 2023 - elifesciences.org
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
Molecular mechanisms governing axonal transport: a C. elegans perspective
A Vasudevan, SP Koushika - Nature's Gift to Neuroscience, 2022 - taylorfrancis.com
Axonal transport is integral for maintaining neuronal form and function, and defects in axonal
transport have been correlated with several neurological diseases, making it a subject of …
transport have been correlated with several neurological diseases, making it a subject of …
loHuntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning
V Hélène, B Julie, H Xu, S Claire, B Jacques, A Yah-Sé… - eLife, 2023 - search.proquest.com
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons
MS Muniesh, SN Barmaver, HY Huang… - Molecular Biology of …, 2020 - Am Soc Cell Biol
UNC-104 is the Caenorhabditis elegans homolog of kinesin-3 KIF1A known for its fast
shuffling of synaptic vesicle protein transport vesicles in axons. SYD-2 is the homolog of …
shuffling of synaptic vesicle protein transport vesicles in axons. SYD-2 is the homolog of …
Methods to Quantify and Relate Axonal Transport Defects to Changes in C. elegans Behavior
SN Barmaver, M Muthaiyan Shanmugam… - … Transport: Methods and …, 2022 - Springer
Neuronal growth, differentiation, homeostasis, viability, and injury response heavily rely on
functional axonal transport (AT). Erroneous and disturbed AT may lead to accumulation of …
functional axonal transport (AT). Erroneous and disturbed AT may lead to accumulation of …
Characterization of TAG‐63 and its role on axonal transport in C. elegans
P Bhan, M Muthaiyan Shanmugam, D Wang… - Traffic, 2020 - Wiley Online Library
Abstract Model organisms are increasingly used to study and understand how neurofilament
(NF)‐based neurological diseases develop. However, whether a NF homolog exists in C …
(NF)‐based neurological diseases develop. However, whether a NF homolog exists in C …
Extreme-value analysis of intracellular cargo transport by motor proteins
Extreme-value analysis (EVA) deals with deviations in the data from the median of the
probability distributions. EVA serves various purposes such as predicting disasters and …
probability distributions. EVA serves various purposes such as predicting disasters and …
A mutation in vesicular acetylcholine transporter increases tubulin acetylation compromising axonal transport
CS Kuo, MC Wang, O Bayansan, SN Barmaver, P Bhan… - bioRxiv, 2024 - biorxiv.org
Kinesin-3 UNC-104 (KIF1A) is the major transporter of synaptic vesicles and genetic defects
in this motor are linked to Charcot-Marie-Tooth disease and hereditary spastic paraplegia. In …
in this motor are linked to Charcot-Marie-Tooth disease and hereditary spastic paraplegia. In …