Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

In response to DNA damage eukaryotic cells activate cell cycle checkpoints—complex
kinase signaling networks that prevent further progression through the cell cycle. Parallel to …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

Purpose Massively parallel sequencing allows simultaneous testing of multiple genes
associated with cancer susceptibility. Guidelines are available for variant classification; …

Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging
DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints …

Publisher Summary This chapter discusses the use of inhibitors of tyrosyl-DNA
phosphodiesterase (Tdp1) and Chk1/2 in combination with Topoisomerase I (TopI) …

In the past decade, CHK2 has emerged as an important multifunctional player in the DNA-
damage response signalling pathway. Parallel studies of the human CHEK2 gene have also …