Our understanding of the significance of epigenetic dysregulation in the pathogenesis of
myeloid malignancies has greatly advanced in the past decade. Enhancer of Zeste Homolog …

Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and
progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique …

Acute myeloid leukaemia (AML) is a rare but severe form of human cancer that results from a
limited number of functionally cooperating genetic abnormalities leading to uncontrolled …

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells,
such as unlimited proliferation and differentiation blockade. Here, we demonstrate that …

Deregulation of transcription is a hallmark of acute myeloid leukemia (AML) that drives
oncogenic expression programs and presents opportunities for therapeutic targeting. By …

Acute myeloid leukemia (AML) is a heterogeneous malignancy affecting myeloid cells in the
bone marrow (BM) but can spread giving rise to impaired hematopoiesis. AML incidence …

This review aims to provide an overview of the current knowledge of the genetic lesions
driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and …

Advances in genome engineering in the last decade, particularly in the development of
programmable nucleases, have made it possible to edit the genomes of most cell types …

Altered metabolism fuels 2 hallmark properties of cancer cells: unlimited proliferation and
differentiation blockade. Adenosine monophosphate–activated protein kinase (AMPK) is a …

Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of
progressing to hematologic malignancies. CH mutations are predominantly found in aged …