Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP4). This new NC/OP4 receptor system belongs to …

The release of transmitter from noradrenergic nerve endings per unit time depends on the
rate of impulse flow on the one hand and the release per impulse on the other hand …

Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–
Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe–Leu–OH. The evidence is based on the …

Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding
in brain homogenates and by depression of contractions of the guinea pig ileum and mouse …

To present a coherent and meaningful survey of scientific research endeavour in an area
that has expanded as fast as physiology and biochemistry of reproduction in the male is no …

We describe the opioid properties of a tridecapeptide, the sequence of which corresponds to
the NH2-terminal sequence of dynorphin, a novel porcine pituitary endorphin. It contains …

Etonitazene and related 2-benzylbenzimidazoles are potent analgetics invented in the
research laboratories of the Swiss pharmaceutical giant CIBA in the late 1950s. Though the …

The structural features responsible for the high potency and opiate receptor specificity of the
opioid peptide dynorphin in the guinea pig ileum myenteric plexus were examined …

The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-
penicillamine, 5-L-penicillamine] enkephalin [(D-Pen2, L-Pen5] enkephalin) and [2-D …

Peptides based on the stabilised tetrapeptide HTyr-D-Ala-Gly-MePheOH have been
synthesised and shown to have substantial opioid activity both in vitro and in vitro. The …