Prognostic biomarkers in oral squamous cell carcinoma: a systematic review
Over the years, several tumor biomarkers have been suggested to foresee the prognosis
oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to …
oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to …
The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome
Both melatonin and proteasome inhibitors upregulate antioxidant enzymes including
superoxide dismutase (SOD), glutathione peroxidase (GP), hemoxygenase 1 (HO-1), and …
superoxide dismutase (SOD), glutathione peroxidase (GP), hemoxygenase 1 (HO-1), and …
Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
E Domenech, C Maestre, L Esteban-Martínez… - Nature cell …, 2015 - nature.com
Blocking mitotic progression has been proposed as an attractive therapeutic strategy to
impair proliferation of tumour cells. However, how cells survive during prolonged mitotic …
impair proliferation of tumour cells. However, how cells survive during prolonged mitotic …
[HTML][HTML] CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway
S Zhao, Y Zhang, X Lu, H Ding, B Han… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Purpose: The incidence of hepatocellular carcinoma (HCC) is extremely high, and China
accounts for approximately 50% of global liver cancer cases. Previous studies reported that …
accounts for approximately 50% of global liver cancer cases. Previous studies reported that …
Phosphorylation of EZH2 by AMPK suppresses PRC2 methyltransferase activity and oncogenic function
Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK),
which coordinates energy status with numerous cellular processes including metabolism …
which coordinates energy status with numerous cellular processes including metabolism …
Targeting Cdc20 as a novel cancer therapeutic strategy
Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …
CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignancies
S Bruno, A Ghelli Luserna di Rorà… - Journal of Experimental …, 2022 - Springer
Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …
controls the correct segregation of chromosomes during mitosis. Many studies have focused …
[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle
Whether glucose is predominantly metabolized via oxidative phosphorylation or glycolysis
differs between quiescent versus proliferating cells, including tumor cells. However, how …
differs between quiescent versus proliferating cells, including tumor cells. However, how …