Foot ulcers are one of the most common and severe complication of diabetes mellitus with
significant resultant morbidity and mortality. Multiple factors impair wound healing include …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT)
is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its …

Free radicals act as secondary messengers, modulating a number of important biological
processes, including gene expression, ion mobilization in transport systems, protein …

Vildagliptin (Vilda), a dipeptidyl peptidase-4 (DPP-4) inhibitor, has been highlighted as a
promising therapeutic agent for neurodegenerative diseases as Alzheimer's and Parkinson's …

Sitagliptin is selective dipeptidyl peptidase-4 inhibitor (DPP4-I), used clinically as a new oral
anti-diabetic agent. This study explored the underlying mechanisms of the hepatoprotective …

Abstract Dipeptidyl peptidase-4 (DPP4) is elevated in numerous cardiovascular pathological
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …

Reactive oxygen species (ROS) have been mainly viewed as unwanted by-products of
cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential …

Due to role of the Keap1–Nrf2 protein–protein interaction (PPI) in protecting cells from
oxidative stress, the development of small molecule inhibitors that inhibit this interaction has …

Atherosclerosis is the leading cause of death worldwide, especially in patients with type 2
diabetes mellitus (T2D). GLP-1 receptor agonists and DPP-4 inhibitors were demonstrated …