Prions, prionoids and protein misfolding disorders

C Scheckel, A Aguzzi - Nature Reviews Genetics, 2018 - nature.com
Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Prion diseases

JW Ironside, DL Ritchie, MW Head - Handbook of clinical neurology, 2018 - Elsevier
The human prion diseases comprise Creutzfeldt–Jakob disease, variably protease-sensitive
prionopathy, Gerstmann–Sträussler–Scheinker disease, fatal familial insomnia, and kuru …

Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease

D Bougard, JP Brandel, M Bélondrade… - Science translational …, 2016 - science.org
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from the
consumption of meat products contaminated by the agent causing bovine spongiform …

Advanced tests for early and accurate diagnosis of Creutzfeldt–Jakob disease

G Zanusso, S Monaco, M Pocchiari… - Nature Reviews …, 2016 - nature.com
Early and accurate diagnosis of Creutzfeldt–Jakob disease (CJD) is a necessary to
distinguish this untreatable disease from treatable rapidly progressive dementias, and to …

Preclinical detection of variant CJD and BSE prions in blood

C Lacroux, E Comoy, M Moudjou… - PLoS …, 2014 - journals.plos.org
The emergence of variant Creutzfeldt Jakob Disease (vCJD) is considered a likely
consequence of human dietary exposure to Bovine Spongiform Encephalopathy (BSE) …

Creutzfeldt‐Jakob disease and blood transfusion safety

CR Seed, PE Hewitt, RY Dodd, F Houston… - Vox …, 2018 - Wiley Online Library
Transmissible spongiform encephalopathies (TSE s) are untreatable, fatal neurologic
diseases affecting mammals. Human disease forms include sporadic, familial and acquired …

First demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse …

P Saá, O Yakovleva, J de Castro, I Vasilyeva… - Journal of Biological …, 2014 - ASBMB
The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of non-
leukoreduced red blood cells from asymptomatic donors who subsequently developed the …

[HTML][HTML] Distribution and quantitative estimates of variant Creutzfeldt-Jakob disease prions in tissues of clinical and asymptomatic patients

JY Douet, C Lacroux, N Aron, MW Head… - Emerging infectious …, 2017 - ncbi.nlm.nih.gov
Abstract In the United-Kingdom,≈ 1 of 2,000 persons could be infected with variant
Creutzfeldt-Jakob disease (vCJD). Therefore, risk of transmission of vCJD by medical …

Prion diseases

MW Head, JW Ironside, B Ghetti, M Jeffrey… - … -Two Volume Set, 2018 - taylorfrancis.com
INTRODUCTION Background Prion diseases, also known as the transmissible spongiform
encephalopathies (TSEs), are rare fatal neurodegenerative diseases affecting humans and …

Public health risks from subclinical variant CJD

AB Diack, RG Will, JC Manson - PLoS pathogens, 2017 - journals.plos.org
Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease thought to have been
transmitted to humans through the consumption of food products contaminated with bovine …