A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Tales of tails in transporters

E Mikros, G Diallinas - Open Biology, 2019 - royalsocietypublishing.org
Cell nutrition, detoxification, signalling, homeostasis and response to drugs, processes
related to cell growth, differentiation and survival are all mediated by plasma membrane …

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

Y Alguel, S Amillis, J Leung, G Lambrinidis… - Nature …, 2016 - nature.com
The uric acid/xanthine H+ symporter, UapA, is a high-affinity purine transporter from the
filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a …

A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients

EJ Byrnes III, W Li, P Ren, Y Lewit, K Voelz… - PLoS …, 2011 - journals.plos.org
Cryptococcus gattii infections in southern California have been reported in patients with
HIV/AIDS. In this study, we examined the molecular epidemiology, population structure, and …

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations

AV Vargiu, F Collu, R Schulz, KM Pos… - Journal of the …, 2011 - ACS Publications
The tripartite efflux pump AcrAB-TolC is responsible for the intrinsic and acquired multidrug
resistance in Escherichia coli. Its active part, the homotrimeric transporter AcrB, is in charge …

Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters

G Diallinas - Frontiers in pharmacology, 2014 - frontiersin.org
Transporters are ubiquitous proteins mediating the translocation of solutes across cell
membranes, a biological process involved in nutrition, signaling, neurotransmission, cell …

Origin, diversification and substrate specificity in the family of NCS 1/FUR transporters

E Krypotou, T Evangelidis, J Bobonis… - Molecular …, 2015 - Wiley Online Library
NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …

Transport‐dependent endocytosis and turnover of a uric acid‐xanthine permease

C Gournas, S Amillis, A Vlanti… - Molecular …, 2010 - Wiley Online Library
In this work we unmask a novel downregulation mechanism of the uric acid/xanthine
transporter UapA, the prototype member of the ubiquitous Nucleobase‐Ascorbate …

Function and regulation of fungal amino acid transporters: Insights from predicted structure

C Gournas, M Prévost, EM Krammer… - Yeast Membrane Transport, 2016 - Springer
Amino acids constitute a major nutritional source for probably all fungi. Studies of model
species such as the yeast Saccharomyces cerevisiae and the filamentous fungus …

The arrestin‐like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad‐range and specific signals

M Karachaliou, S Amillis, M Evangelinos… - Molecular …, 2013 - Wiley Online Library
We investigated the role of all arrestin‐like proteins of A spergillus nidulans in respect to
growth, morphology, sensitivity to drugs and specifically for the endocytosis and turnover of …