The underlying role of inflammation in atherosclerosis has been characterized. However,
current treatment of coronary artery disease (CAD) predominantly consists of targeted …

Filamin A (FLNA) is a large actin-binding cytoskeletal protein that is important for cell motility
by stabilizing actin networks and integrating them with cell membranes. Interestingly, a C …

SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung
inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal …

The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …

To investigate the evolutionary origins of proteins encoded by the Poxviridae family of
viruses, we examined all poxvirus protein coding genes using a method of characterizing …

Serine proteases drive important physiological processes such as coagulation, fibrinolysis,
inflammation and angiogenesis. These proteases are controlled by serine protease …

Immunopathogenesis in systemic viral infections can induce a septic state with leaky
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …

Spinal cord injury (SCI) results in massive secondary damage characterized by a prolonged
inflammation with phagocytic macrophage invasion and tissue destruction. In prior work …

The prevalence of diabetes has been rapidly increasing in world-wide countries. The
dominant cause of mortality in diabetic patients is cardiovascular complications. Mechanism …