Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction
P Calabresi, A Mechelli, G Natale… - Cell death & …, 2023 - nature.com
Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …
The physiological role of α‐synuclein and its relationship to Parkinson's Disease
D Sulzer, RH Edwards - Journal of neurochemistry, 2019 - Wiley Online Library
The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …
In this review, we discuss recent results concerning its primary function, which appears to be …
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …
was identified as an important player in a complex neurodegenerative disease that affects> …
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …
Cell biology and pathophysiology of α-synuclein
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
The bowel and beyond: the enteric nervous system in neurological disorders
M Rao, MD Gershon - Nature reviews Gastroenterology & hepatology, 2016 - nature.com
The enteric nervous system (ENS) is large, complex and uniquely able to orchestrate
gastrointestinal behaviour independently of the central nervous system (CNS). An intact …
gastrointestinal behaviour independently of the central nervous system (CNS). An intact …
Interaction of mitochondrial calcium and ROS in neurodegeneration
AY Baev, AY Vinokurov, IN Novikova, VV Dremin… - Cells, 2022 - mdpi.com
Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …
characterized by the slow and progressive loss of neurons in specific brain regions …
Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases
D Rufino-Ramos, PR Albuquerque, V Carmona… - Journal of Controlled …, 2017 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles virtually secreted by all
cells, including brain cells. EVs are a major term that includes apoptotic bodies …
cells, including brain cells. EVs are a major term that includes apoptotic bodies …
Mechanisms of α-synuclein induced synaptopathy in Parkinson's disease
JC Bridi, F Hirth - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …
Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson's disease
The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …