Features of third generation photosensitizers used in anticancer photodynamic therapy
IS Mfouo-Tynga, LD Dias, NM Inada… - … and photodynamic therapy, 2021 - Elsevier
Cancer remains a main public health issue and the second cause of mortality worldwide.
Photodynamic therapy is a clinically approved therapeutic option. Effective photodynamic …
Photodynamic therapy is a clinically approved therapeutic option. Effective photodynamic …
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
F Kruiswijk, CF Labuschagne… - Nature reviews Molecular …, 2015 - nature.com
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …
[HTML][HTML] Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis
R Yuan, W Zhao, QQ Wang, J He, S Han, H Gao… - Pharmacological …, 2021 - Elsevier
Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …
Targeting ferroptosis in breast cancer
Z Li, L Chen, C Chen, Y Zhou, D Hu, J Yang, Y Chen… - Biomarker …, 2020 - Springer
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …
[HTML][HTML] Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and …
Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …
Organelle-specific initiation of cell death
In a majority of pathophysiological settings, cell death is not accidental—it is controlled by a
complex molecular apparatus. Such a system operates like a computer: it receives several …
complex molecular apparatus. Such a system operates like a computer: it receives several …
Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms
Air pollution is one of the leading causes of deaths in Southeast Asian countries including
India. Exposure to air pollutants affects vital cellular mechanisms and is intimately linked …
India. Exposure to air pollutants affects vital cellular mechanisms and is intimately linked …
[HTML][HTML] p53 and metabolism: from mechanism to therapeutics
The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
[HTML][HTML] p53 and mitochondrial function in neurons
DB Wang, C Kinoshita, Y Kinoshita… - Biochimica et Biophysica …, 2014 - Elsevier
The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …
Unfolded protein response in colorectal cancer
J Huang, H Pan, J Wang, T Wang, X Huo, Y Ma, Z Lu… - Cell & bioscience, 2021 - Springer
Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …