Cancer remains a main public health issue and the second cause of mortality worldwide.
Photodynamic therapy is a clinically approved therapeutic option. Effective photodynamic …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Pyroptosis, a type of programmed cell death (PCD), is characterized by cell swelling with
bubbles, and the release of inflammatory cell cytokines. Cucurbitacin B (CuB), extracted …

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …

In a majority of pathophysiological settings, cell death is not accidental—it is controlled by a
complex molecular apparatus. Such a system operates like a computer: it receives several …

Air pollution is one of the leading causes of deaths in Southeast Asian countries including
India. Exposure to air pollutants affects vital cellular mechanisms and is intimately linked …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …

Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or
the rectum. A growing number of researches prove that the unfolded protein response (UPR) …