Recent therapeutic advancements in understanding of molecular and cellular mechanisms
of rheumatoid arthritis (RA) have highlighted the strategies that aim to inhibit the harmful …

Introduction: Spontaneous preterm birth (PTB) and preterm premature rupture of the
membranes (pPROM) remain as a major clinical and therapeutic problem for intervention …

Abstract Development of novel drugs for treatment of chronic inflammatory diseases is to a
large extent dependent on the availability of good experimental in vivo models in order to …

Objective To summarise the adverse events (AE) reported in patients with rheumatoid
arthritis (RA) treated with protein kinase inhibitors (PKi), and identify family and molecule …

Stimulation via the T-cell receptor (TCR) activates p38α and p38β by phosphorylation of p38
Tyr-323 (p38Y323). Here we characterize knockin mice in which p38α and/or β Tyr-323 has …

Context: Clematichinenoside (AR-6) is a triterpene saponin from an anti-arthritic herbal
formula Wei-Ling-Xian in Chinese, which is an herbal medicine derived from the dried root …

Inhaled glucocorticoids, also know as corticosteroids (ICS), revolutionized the treatment of
asthma by suppressing airways inflammation and ICS therapy now forms the basis of …

We have optimized a novel series of potent p38 MAP kinase inhibitors based on an α-
ketoamide scaffold through structure based design that due to their extended molecular …

p38 mitogen-activated protein (MAP) kinases are the serine/threonine protein kinases,
which play a vital role in cellular responses to external stress signals. p38 MAP kinase …

Quadriceps weakness is associated with a poor prognosis in COPD. Several data suggest
that immobility and muscle wasting may be related through up-regulation of the p38 Mitogen …