Skin pigmentation is an important human phenotypic trait whose regulation, in spite of recent
advances, has not yet been fully understood. The pigment melanin is produced in …

Please cite this paper as:“Transcription physiology” of pigment formation in melanocytes:
central role of (MITF). Experimental Dermatology 2010; 19: 617–627. Abstract: Melanin …

UV-induced pigmentation (suntanning) requires induction of α-melanocyte-stimulating
hormone (α-MSH) secretion by keratinocytes. α-MSH and other bioactive peptides are …

Many agents affect the transmission of ultraviolet light to human skin. These include
naturally occurring photoprotective agents (ozone, pollutants, clouds, and fog), naturally …

Despite many efforts, regulation of skin and hair pigmentation is still not fully understood.
This article focuses mainly on controversial aspects in pigment cell biology which have …

Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …

The melanocortin 1 receptor (MC 1R) is a G protein‐coupled receptor crucial for the
regulation of melanocyte proliferation and function. Upon binding melanocortins, MC 1R …

Recent years have seen a steady rise in the incidence of cutaneous malignant melanoma
worldwide. Although it is now appreciated that the key to understanding the process by …

Exposure to ultra violet radiation (UVR) is associated with significant long-term deleterious
effects such as skin cancer. A well-recognised short-term consequence of UVR is increased …

Abnormally high production of melanin or melanogenesis in skin melanocytes results in
hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These …