Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Direct protein sequencing technologies with improved sensitivity and throughput are still
needed. Here, we propose an alternative method for peptide sequencing based on …

Efforts to sequence single protein molecules in nanopores,,,–have been hampered by the
lack of techniques with sufficient sensitivity to discern the subtle molecular differences …

Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their
highly variable amino acid sequences. The technology allowing for direct analysis of protein …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

The chemical nature and precise position of posttranslational modifications (PTMs) in
proteins or peptides are crucial for various severe diseases, such as cancer. State-of-the-art …

Single-molecule measurements have greatly enhanced our understanding of living systems.
Biological systems offer nanopores, a sub-class of membrane proteins, the well-defined …

Nanopores are promising sensing devices that can be used for the detection of analytes at
the single molecule level. It is of importance to understand and model the current response …

Changes in the nanopore ionic current during entry of a target molecule underlie the
sensing capability and dominate the intensity and extent of applications of the nanopore …