Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Precision medicine in human heart modeling: perspectives, challenges, and opportunities

M Peirlinck, FS Costabal, J Yao, JM Guccione… - … and modeling in …, 2021 - Springer
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

D Dicker, G Nguyen, D Abate, KH Abate, SM Abay… - The lancet, 2018 - thelancet.com
Background Assessments of age-specific mortality and life expectancy have been done by
the UN Population Division, Department of Economics and Social Affairs (UNPOP), the …

Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function

A Quarteroni, T Lassila, S Rossi… - Computer Methods in …, 2017 - Elsevier
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach

T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

Fully coupled fluid‐electro‐mechanical model of the human heart for supercomputers

A Santiago, J Aguado‐Sierra… - … journal for numerical …, 2018 - Wiley Online Library
In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …

A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes

S Land, SJ Park-Holohan, NP Smith… - Journal of molecular and …, 2017 - Elsevier
Experimental data from human cardiac myocytes at body temperature is crucial for a
quantitative understanding of clinically relevant cardiac function and development of whole …

Hybrid finite difference/finite element immersed boundary method

BE Griffith, X Luo - … journal for numerical methods in biomedical …, 2017 - Wiley Online Library
The immersed boundary method is an approach to fluid‐structure interaction that uses a
Lagrangian description of the structural deformations, stresses, and forces along with an …

Creation and application of virtual patient cohorts of heart models

SA Niederer, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …