Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

Associations between gut microbiota and colorectal cancer (CRC) have been widely
investigated. However, the replicable markers for early-stage adenoma diagnosis across …

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential hub that
integrates nutrient signals and coordinates metabolism to control cell growth. Amino acid …

Metastasis is the leading cause of death for colorectal cancer (CRC) patients, and the
spreading tumor cells adhesion to endothelial cells is a critical step for extravasation and …

Antibacterial autophagy (xenophagy) is an important host defense, but how it is initiated is
unclear. Here, we performed a bacterial transposon screen and identified a T3SS effector …

Sepsis is defined as life-threatening organ dysfunction caused by the dysregulated host
response to infection. Despite serious mortality and morbidity, no sepsis-specific drugs exist …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied …