The ARP2/3 complex: an actin nucleator comes of age
The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …
initiation of actin polymerization and the organization of the resulting filaments. The actin …
The WASP–WAVE protein network: connecting the membrane to the cytoskeleton
T Takenawa, S Suetsugu - Nature reviews Molecular cell biology, 2007 - nature.com
Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …
[HTML][HTML] Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells
C Yang, L Czech, S Gerboth, S Kojima, G Scita… - PLoS …, 2007 - journals.plos.org
Actin polymerization-driven protrusion of the leading edge is a key element of cell motility.
The important actin nucleators formins and the Arp2/3 complex are believed to have …
The important actin nucleators formins and the Arp2/3 complex are believed to have …
Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation
A Steffen, K Rottner, J Ehinger, M Innocenti… - The EMBO …, 2004 - embopress.org
The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …
Filopodia and their links with membrane traffic and cell adhesion
JL Gallop - Seminars in cell & developmental biology, 2020 - Elsevier
Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin
filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell …
filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell …
The making of filopodia
J Faix, K Rottner - Current opinion in cell biology, 2006 - Elsevier
Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments.
They are found on a variety of cell types and have been ascribed sensory or exploratory …
They are found on a variety of cell types and have been ascribed sensory or exploratory …
Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
G Benítez‐King - Journal of pineal research, 2006 - Wiley Online Library
The cytoskeleton is a phylogenetically well‐preserved structure that plays a key role in cell
physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular …
physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular …
[HTML][HTML] Filopodia as sensors
CA Heckman, HK Plummer III - Cellular signalling, 2013 - Elsevier
Filopodia are sensors on both excitable and non-excitable cells. The sensing function is well
documented in neurons and blood vessels of adult animals and is obvious during dorsal …
documented in neurons and blood vessels of adult animals and is obvious during dorsal …
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory
SH Soderling, ES Guire, S Kaech, J White… - Journal of …, 2007 - Soc Neuroscience
The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs
signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin …
signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin …
[HTML][HTML] A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein
A Yamagishi, M Masuda, T Ohki, H Onishi… - Journal of Biological …, 2004 - ASBMB
Insulin receptor tyrosine kinase substrate p53 (IRSp53) has been identified as an SH3
domain-containing adaptor that links Rac1 with a Wiskott-Aldrich syndrome family verprolin …
domain-containing adaptor that links Rac1 with a Wiskott-Aldrich syndrome family verprolin …