The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

Wiskott–Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein
(WAVE) family proteins are scaffolds that link upstream signals to the activation of the …

Actin polymerization-driven protrusion of the leading edge is a key element of cell motility.
The important actin nucleators formins and the Arp2/3 complex are believed to have …

The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals
to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization …

Filopodia are dynamic, narrow, plasma membrane protrusions filled with bundled actin
filaments. Fresh actin monomers are incorporated at the tips furthest away from the cell …

Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments.
They are found on a variety of cell types and have been ascribed sensory or exploratory …

The cytoskeleton is a phylogenetically well‐preserved structure that plays a key role in cell
physiology. Dynamic and differential changes in cytoskeletal organization occur in cellular …

Filopodia are sensors on both excitable and non-excitable cells. The sensing function is well
documented in neurons and blood vessels of adult animals and is obvious during dorsal …

The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs
signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin …

Insulin receptor tyrosine kinase substrate p53 (IRSp53) has been identified as an SH3
domain-containing adaptor that links Rac1 with a Wiskott-Aldrich syndrome family verprolin …