Objectives This review attempts to bring together information from a large number of recent
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …

Aspirin, arguably the world's favourite drug, has been around since the late nineteenth
century, but it wasn't until the late 1970s that its ability to inhibit prostaglandin production by …

Two cyclooxygenase isozymes, COX-1 and-2, are known to catalyze the rate-limiting step of
prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we …

It has been recently demonstrated that interleukin 1β (IL-1β) plays a central role in
monosodium urate crystal–induced inflammation and that the NALP3 inflammasome plays a …

To compare the efficacy and adverse effects of celecoxib, a cyclooxygenase-2 (COX-2)
inhibitor, with naproxen, a non-steroidal anti-inflammatory drug, and placebo in the …

The mechanism by which COX inhibitors exert their analgesic effect is well established.
However, data show no direct correlation between drug concentrations in plasma and the …

Abstract Treatment of osteoarthritis (OA) with nonsteroidal anti-inflammatory drugs (NSAIDs)
diminishes inflammation along with mediators of cartilage destruction. However, NSAIDs …

The discovery of ibuprofen's anti‐inflammatory activity by Dr (now Professor) Stewart Adams
and colleagues (Boots Pure Chemical Company Ltd, Nottingham, UK) 50 years ago …

There are several pre-clinical studies on the involvement of NO in inflammation. From this
large amount of information it is clear that virtually every cell and many immunological …

Despite the availability of effective urate-lowering therapy (ULT) and anti-inflammatory drugs
for the treatment of gout, there is considerable interest in novel treatment approaches …