Telomeres and telomerase in cardiovascular diseases

JK Yeh, CY Wang - Genes, 2016 - mdpi.com
Telomeres are tandem repeat DNA sequences present at the ends of each eukaryotic
chromosome to stabilize the genome structure integrity. Telomere lengths progressively …

Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis

E Ammirati, F Moroni, GD Norata… - Mediators of …, 2015 - Wiley Online Library
Atherosclerosis is the focal expression of a systemic disease affecting medium‐and large‐
sized arteries, in which traditional cardiovascular risk factor and immune factors play a key …

Regulatory T cell migration is dependent on glucokinase-mediated glycolysis

M Kishore, KCP Cheung, H Fu, F Bonacina, G Wang… - Immunity, 2017 - cell.com
Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-
modulatory function. While metabolic reprogramming during Treg cell differentiation has …

[HTML][HTML] Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions

P Bontempo, L Capasso, L De Masi, A Nebbioso… - Nutrients, 2024 - mdpi.com
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …

Somatic comorbidity in schizophrenia: some possible biological mechanisms across the life span

I Dieset, OA Andreassen, UK Haukvik - Schizophrenia bulletin, 2016 - academic.oup.com
Schizophrenia is associated with decreased life expectancy (15–25 y) compared to the
general population, with comorbid somatic diseases and in particular cardiovascular …

P2X7 receptor activity limits accumulation of T cells within tumors

A Romagnani, E Rottoli, EMC Mazza, T Rezzonico-Jost… - Cancer research, 2020 - AACR
Extracellular ATP (eATP) is a signaling molecule that variably affects all cells of the immune
system either directly or after hydrolysis to adenosine. Although eATP is virtually absent in …

Telomere length maintenance and cardio-metabolic disease prevention through exercise training

J Denham, BJ O'Brien, FJ Charchar - Sports medicine, 2016 - Springer
Telomeres are tandem repeat DNA sequences located at distal ends of chromosomes that
protect against genomic DNA degradation and chromosomal instability. Excessive telomere …

Novel therapeutical approaches to managing atherosclerotic risk

RV Giglio, A Pantea Stoian, K Al-Rasadi… - International Journal of …, 2021 - mdpi.com
Atherosclerosis is a multifactorial vascular disease that leads to inflammation and stiffening
of the arteries and decreases their elasticity due to the accumulation of calcium, small dense …

Sex differences in effects of maternal risk and protective factors in childhood and pregnancy on newborn telomere length

MB Enlow, V Bollati, G Sideridis, JD Flom… - …, 2018 - Elsevier
Little research has examined determinants of newborn telomere length, a potential
biomarker of lifetime disease risk impacted by prenatal exposures. No study has examined …

Maternal cortisol output in pregnancy and newborn telomere length: Evidence for sex-specific effects

MB Enlow, G Sideridis, V Bollati, M Hoxha… - …, 2019 - Elsevier
Newborn telomere length is a potential biomarker of the effects of maternal-fetal processes
on offspring long-term health. A number of maternal psychosocial and environmental factors …