Lung cancer is the leading cause of cancer-related mortality not only in the United States but
also around the world. In North America, lung cancer has become more predominant among …

The inactivation of programmed cell death, or apoptosis, is central to the development of
cancer. This disabling of apoptotic responses might be a major contributor both to treatment …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

PURPOSE We evaluated the role of oxaliplatin as adjuvant chemotherapy in patients with
rectal cancer who received preoperative chemoradiotherapy (CRT) with fluoropyrimidine …

Human cancers exhibit genomic instability and an increased mutation rate due to underlying
defects in DNA repair. Cancer cells are often defective in one of six major DNA repair …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Platinum chemotherapeutic agents such as cisplatin are currently used in the treatment of
various malignancies such as lung cancer. However, their efficacy is significantly hindered …

Advanced cancer is the second leading cause of death in the western world. Chemotherapy
and radiation are the two main treatment modalities currently available to improve patient …

Purpose To explore whether population-related pharmacogenomics contribute to
differences in patient outcomes between clinical trials performed in Japan and the United …