Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Poisoning by paraquat herbicide is a major medical problem in parts of Asia while sporadic
cases occur elsewhere. The very high case fatality of paraquat is due to inherent toxicity and …

Acetaminophen hepatotoxicity is the leading cause of drug-induced liver failure. Despite
substantial efforts in the past, the mechanisms of acetaminophen-induced liver cell injury are …

Intracellular sources of peroxynitrite formation and potential targets for this powerful oxidant
and nitrating agent have not been identified after acetaminophen (AAP) overdose …

Boronates, a group of organic compounds, are emerging as one of the most effective probes
for detecting and quantifying peroxynitrite, hypochlorous acid, and hydrogen peroxide …

Oxidative therapy, which generates reactive oxygen species (ROS) via intracellular
enzymatic reactions to achieve tumor ablation, is considered as an emerging approach to …

Parkinson's disease is one of the most common neurodegenerative disease found in aged
peoples. Plentiful studies are being conducted to find a suitable and effective cure for this …

Context: Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known
agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid …

Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic
multisymptom illness, and a potential model for accelerated aging. Inflammation is the main …