Chemical communication at the synthetic cell/living cell interface
Although the complexity of synthetic cells has continued to increase in recent years,
chemical communication between protocell models and living organisms remains a key …
chemical communication between protocell models and living organisms remains a key …
Hydrogels in emerging technologies for type 1 diabetes
Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …
painless manner for patients has remained a central focus of next-generation diabetes …
The potential of hyaluronic acid in immunoprotection and immunomodulation: Chemistry, processing and function
Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many
parts of the body. It is a material of increasing importance to biomaterials science and is …
parts of the body. It is a material of increasing importance to biomaterials science and is …
Immunological and technical considerations in application of alginate-based microencapsulation systems
GA Paredes Juárez, M Spasojevic, MM Faas… - … in bioengineering and …, 2014 - frontiersin.org
Islets encapsulated in immunoprotective microcapsules are being proposed as an
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …
alternative for insulin therapy for treatment of type 1 diabetes. Many materials for producing …
All-aqueous-phase microfluidics for cell encapsulation
Cell-laden hydrogel microcarriers are widely used in diverse biomedical applications like
three-dimensional (3D) cell culture, cellular therapy, and tissue engineering, where …
three-dimensional (3D) cell culture, cellular therapy, and tissue engineering, where …
[HTML][HTML] Protein delivery into the cell cytosol using non-viral nanocarriers
YW Lee, DC Luther, JA Kretzmann, A Burden… - Theranostics, 2019 - ncbi.nlm.nih.gov
Protein delivery into cells is a potentially transformative tool for treating “undruggable”
targets in diseases associated with protein deficiencies or mutations. The vast majority of …
targets in diseases associated with protein deficiencies or mutations. The vast majority of …
Modulating the foreign body response of implants for diabetes treatment
Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …
patients' inability to produce sufficient insulin. Current interventions often require implants …
[HTML][HTML] Labile crosslinked hyaluronic acid via urethane formation using bis (β-isocyanatoethyl) disulphide with tuneable physicochemical and immunomodulatory …
Here, we synthesise a new isocyanate-based crosslinker with the aim of obtaining novel
tailored gels. The newly crosslinked hyaluronic acid (HA) gels were analysed in terms of …
tailored gels. The newly crosslinked hyaluronic acid (HA) gels were analysed in terms of …
A safe, fibrosis‐mitigating, and scalable encapsulation device supports long‐term function of insulin‐producing cells
Encapsulation and transplantation of insulin‐producing cells offer a promising curative
treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials …
treatment for type 1 diabetes (T1D) without immunosuppression. However, biomaterials …
Nanoporous immunoprotective device for stem-cell-derived β-cell replacement therapy
Encapsulation of human embryonic stem-cell-differentiated beta cell clusters (hES-βC) holds
great promise for cell replacement therapy for the treatment of diabetics without the need for …
great promise for cell replacement therapy for the treatment of diabetics without the need for …