Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue …

P Lips, KD Cashman, C Lamberg-Allardt… - European journal of …, 2019 - academic.oup.com
Vitamin D deficiency (serum 25-hydroxyvitamin D (25 (OH) D)< 50 nmol/L or 20 ng/mL) is
common in Europe and the Middle East. It occurs in< 20% of the population in Northern …

The bone remodelling cycle

JS Kenkre, JHD Bassett - Annals of clinical biochemistry, 2018 - journals.sagepub.com
The bone remodelling cycle replaces old and damaged bone and is a highly regulated,
lifelong process essential for preserving bone integrity and maintaining mineral …

Interdisciplinary management of FGF23-related phosphate wasting syndromes: a consensus statement on the evaluation, diagnosis and care of patients with X-linked …

A Trombetti, N Al-Daghri, ML Brandi… - Nature Reviews …, 2022 - nature.com
X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

[HTML][HTML] Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis

J He, S Xu, B Zhang, C Xiao, Z Chen, F Si, J Fu… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Reduced bone mineral density (BMD) is associated with an altered microbiota in senile
osteoporosis. However, the relationship among gut microbiota, BMD and bone metabolic …

Biology and mechanisms of action of the vitamin D hormone

JW Pike, S Christakos - Endocrinology and Metabolism Clinics, 2017 - endo.theclinics.com
Discovered many decades earlier by Mellanby, 1 McCollum and colleagues, 2 Steenbock, 3
and Windaus and colleagues, 4 vitamin D is now known through ensuing research efforts by …

[HTML][HTML] Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery

CS Kovacs - Physiological reviews, 2016 - journals.physiology.org
During pregnancy and lactation, female physiology adapts to meet the added nutritional
demands of fetuses and neonates. An average full-term fetus contains∼ 30 g calcium, 20 g …

FGF23 and its role in X-linked hypophosphatemia-related morbidity

SS Beck-Nielsen, Z Mughal, D Haffner… - Orphanet Journal of …, 2019 - Springer
Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

[HTML][HTML] Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

NA Sims, TJ Martin - BoneKEy reports, 2014 - ncbi.nlm.nih.gov
Coupling between bone formation and bone resorption refers to the process within basic
multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts …