Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

The receptors involved in bitter taste perception (bitter taste receptors—T2Rs) constitute a
family of G-protein-coupled receptors, of which around 29 subtypes have been identified in …

Background and Purpose Sustained pulmonary vasoconstriction and excessive pulmonary
vascular remodelling are two major causes of elevated pulmonary vascular resistance in …

Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few
prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining …

Inspired by the well-known phenomenon of stretch-induced airway dilation in normal lungs
and the emerging stretch-responsive Piezo1 channels that can be chemically activated by …

Because of the serious side effects of the currently used bronchodilators, new compounds
with similar functions must be developed. We screened several herbs and found that …

Bitter taste receptors (TAS2Rs) are traditionally thought to be expressed exclusively on the
taste buds of the tongue. However, accumulating evidence has indicated that this receptor …

Abstract lntracellular calcium ion is the key secondary messenger system of the cellular
processes in airway smooth muscle cells (ASMc). The treatment and regulation of Ca2+ in …

Asthma is a common heterogeneous respiratory disease characterized by airway
inflammation and airway hyperresponsiveness (AHR) which is associated with abnormality …

Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive
pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM …