Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory
neurons where it acts as a sensor for environmental irritants, including acrolein, and some …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Ion channels are important therapeutic targets due to their plethoric involvement in
physiological and pathological consequences. The transient receptor potential cation …

The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …