▪ Abstract Early development of the vertebrate skeleton depends on genes that pattern the
distribution and proliferation of cells from cranial neural crest, sclerotomes, and lateral plate …

BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

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The DiGeorge/velocardiofacial syndrome (DGS/VCFS) is a relatively common human
disorder, usually associated with deletions of chromosome 22q11. The genetic basis for the …

Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs.
Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used …

A wealth of information has recently become available on the molecular signals that are
required to form and pattern the dentition in the mouse, shedding light on how important …

Congenitally missing teeth (CMT), or as usually called hypodontia, is a highly prevalent and
costly dental anomaly. Besides an unfavorable appearance, patients with missing teeth may …

Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

More than 300 genes have so far been associated with tooth development, mainly in mouse
embryos. The majority of them are associated with conserved signaling pathways mediating …

Pax genes encode a family of transcription factors that orchestrate complex processes of
lineage determination in the developing embryo. Their key role is to specify and maintain …