Role of biophysics and mechanobiology in podocyte physiology

J Haydak, EU Azeloglu - Nature Reviews Nephrology, 2024 - nature.com
Podocytes form the backbone of the glomerular filtration barrier and are exposed to various
mechanical forces throughout the lifetime of an individual. The highly dynamic …

Ultrafast shape‐reconfigurable chiral mechanical metamaterial based on prestressed bistable shells

Y Liu, F Pan, F Xiong, Y Wei, Y Ruan… - Advanced Functional …, 2023 - Wiley Online Library
Fast shape‐reconfiguration with large morphing amplitude is crucial for intelligent
materials/structures that require tunable functions and adaptivity to different environments …

SEMA3B inhibits TGFβ-induced extracellular matrix protein production and its reduced levels are associated with a decline in lung function in IPF

DJK Yombo, S Ghandikota… - … of Physiology-Cell …, 2024 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is marked by the activation of fibroblasts, leading to
excessive production and deposition of extracellular matrix (ECM) within the lung …

Gradient Bipolar Nanofiber Scaffolds with a Structure of Biomimetic Tendon-Bone Interface as Rotator Cuff Patches

P Shang, Y Xiang, J Du, S Chen, B Cheng… - ACS Applied Polymer …, 2023 - ACS Publications
Due to the special three-dimensional gradient structure from the bone to tendon at the
tendon-bone interface (TBI), it is difficult to achieve a good therapeutic effect after rotator cuff …

SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation

YQ Wang, H Chen, S Xu, CR Liao, A Xu, Y Han… - MedComm, 2023 - Wiley Online Library
Mounting evidence has demonstrated the considerable regulatory effects of long noncoding
RNAs (lncRNAs) in the tumorigenesis and progression of various carcinomas. LncRNA …

[HTML][HTML] Single-cell and Bulk RNA-Seq reveal angiogenic heterogeneity and microenvironmental features to evaluate prognosis and therapeutic response in lung …

L Tang, Z Chen, J Yang, Q Li, S Wang, T Mo… - Frontiers in …, 2024 - frontiersin.org
Background Angiogenesis stands as a pivotal hallmark in lung adenocarcinoma (LUAD),
intricately shaping the tumor microenvironment (TME) and influencing LUAD progression. It …

[HTML][HTML] Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

X Cai, C Warburton, OF Perez, Y Wang, L Ho, C Finelli… - Iscience, 2024 - cell.com
Recent studies have implicated a crucial role of Hippo signaling in cell fate determination by
biomechanical signals. Here we show that mechanical loading triggers the activation of a …

[HTML][HTML] Unveiling the role of hypoxic macrophage-derived exosomes in driving colorectal cancer progression

J Jiang, W Wang, L Zhu, B Shi, Y Chen, Y Xia… - Frontiers in …, 2023 - frontiersin.org
The crosstalk between tumor cells and macrophages under hypoxic conditions has been
acknowledged as a pivotal determinant in the progression of colorectal cancer (CRC) …

[HTML][HTML] Hippo Signaling Modulates the Inflammatory Response of Chondrocytes to Mechanical Compressive Loading

X Cai, C Warburton, OF Perez, Y Wang, L Ho, C Finelli… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload,
where direct physical impacts on chondrocytes play a crucial role in disease development …

[HTML][HTML] Exploring lncRNA Expression Patterns in Patients With Hypertrophied Ligamentum Flavum

J Chen, G Zhong, M Qiu, W Ke, J Xue, J Chen - Neurospine, 2024 - ncbi.nlm.nih.gov
Objective Hypertrophy ligamentum flavum (LFH) is a common cause of lumbar spinal
stenosis, resulting in significant disability and morbidity. Although long noncoding RNAs …