Hydroxynorketamines (HNKs) are formed in vivo after (R, S)-ketamine (ketamine)
administration. The 12 HNK stereoisomers are distinguished by the position of cyclohexyl …

Ketamine is regaining popularity in the field of anesthesia and beyond. New studies provide
insight on the many indications and use that anesthesia providers may encounter during …

The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising
developments for the treatment of depression. Nevertheless, racemic ketamine and (S) …

For decades, symptoms of depression have been treated primarily with medications that
directly target the monoaminergic brain systems, which typically take weeks to exert …

Although surgical resection provides a straightforward and effective treatment for most
malignant solid tumors, tumor recurrence and acute postoperative pain continue to be two …

A single, subanesthetic dose of (R, S)-ketamine (ketamine) exerts rapid and robust
antidepressant effects. Several groups previously reported that (2S, 6S; 2R, 6R) …

Pain is the leading cause of medical consultations and occurs in 50–70% of emergency
department visits. To date, several drugs have been used to manage pain. The clinical use …

Background:(R, S)-ketamine has gained attention for its rapid-acting antidepressant actions
in patients with treatment-resistant depression. However, widespread use of ketamine is …

Background Chronic primary pain (CPP) is an intractable pain of unknown cause with
significant emotional distress and/or dysfunction that is a leading factor of disability globally …

Abstract Purpose of Review While ketamine's analgesia has mostly been attributed to
antagonism of N-methyl-d-aspartate receptors, evidence suggests multiple other pathways …