Introduction Continuous advances in mass spectrometry (MS) technologies have enabled
deeper and more reproducible proteome characterization and a better understanding of …

Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …

Protein aggregation of amyloid-β peptides and tau are pathological hallmarks of Alzheimer's
disease (AD), which are often resistant to detergent extraction and thus enriched in the …

Sample multiplexed quantitative proteomics assays have proved to be a highly versatile
means to assay molecular phenotypes. Yet, stochastic precursor selection and precursor …

Proteolytic processing is the most ubiquitous post-translational modification and regulator of
protein function. To identify protease substrates, and hence the function of proteases …

We describe einprot, an R package providing easy-to-use reproducible workflows for quality
control, statistical analysis and visualization of quantitative proteomics data. einprot is …

Matrisome-associated heparin binding proteins (HBPs) with roles in extracellular matrix
assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease …

Clinical metaproteomics has the potential to offer insights into the host-microbiome
interactions underlying diseases. However, the field faces challenges in characterizing …

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor originating from proximal
tubular epithelial cells, and despite extensive research efforts, its redox homeostasis …

Methods: We employed heparin affinity chromatography, followed by off-line fractionation
and tandem mass tag mass spectrometry (TMT-MS), to capture and enrich HBPs in plasma …