Glycosaminoglycans in extracellular matrix organisation: are concepts from soft matter physics key to understanding the formation of perineuronal nets?
Highlights•Glycosaminoglycan physical properties contribute to distinct biochemical
functions.•Hyaluronan is a unique scaffolding material, enabling matrix self …
functions.•Hyaluronan is a unique scaffolding material, enabling matrix self …
Glycosaminoglycans modulate long-range mechanical communication between cells in collagen networks
Cells can sense and respond to mechanical forces in fibrous extracellular matrices (ECMs)
over distances much greater than their size. This phenomenon, termed long-range force …
over distances much greater than their size. This phenomenon, termed long-range force …
Structure and function of the endothelial surface layer: unraveling the nanoarchitecture of biological surfaces
BP Reines, BW Ninham - Quarterly reviews of biophysics, 2019 - cambridge.org
Among the unsolved mysteries of modern biology is the nature of a lining of blood vessels
called the 'endothelial surface layer'or ESL. In venous micro-vessels, it is half a micron in …
called the 'endothelial surface layer'or ESL. In venous micro-vessels, it is half a micron in …
Liquid-like solids support cells in 3D
The demands of tissue engineering have driven a tremendous amount of research effort in
3D tissue culture technology and, more recently, in 3D printing. The need to use 3D tissue …
3D tissue culture technology and, more recently, in 3D printing. The need to use 3D tissue …
Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan
Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …
Collective dynamics effect transient subdiffusion of inert tracers in flexible gel networks
Based on extensive Brownian dynamics simulations we study the thermal motion of a tracer
bead in a cross-linked, flexible gel in the limit when the tracer particle size is comparable to …
bead in a cross-linked, flexible gel in the limit when the tracer particle size is comparable to …
Functional organization of extracellular hyaluronan, CD44, and RHAMM
The integral membrane protein CD44 is constitutively expressed in most tissues, and is the
primary cell surface receptor for hyaluronan (HA). HA is the key scaffolding organizer of …
primary cell surface receptor for hyaluronan (HA). HA is the key scaffolding organizer of …
Strategies and processes to decellularize and recellularize hearts to generate functional organs and reduce the risk of thrombosis
N Momtahan, S Sukavaneshvar… - … Engineering Part B …, 2015 - liebertpub.com
Heart failure is one of the leading causes of death in the United States. Current therapies,
such as heart transplants and bioartificial hearts, are helpful, but not optimal …
such as heart transplants and bioartificial hearts, are helpful, but not optimal …
K+ and Ca2+ Channels Regulate Ca2+ Signaling in Chondrocytes: An Illustrated Review
Y Suzuki, H Yamamura, Y Imaizumi, RB Clark… - Cells, 2020 - mdpi.com
An improved understanding of fundamental physiological principles and progressive
pathophysiological processes in human articular joints (eg, shoulders, knees, elbows) …
pathophysiological processes in human articular joints (eg, shoulders, knees, elbows) …
Micromechanical analysis of the hyaluronan-rich matrix surrounding the oocyte reveals a uniquely soft and elastic composition
The cumulus cell-oocyte complex (COC) matrix is an extended coat that forms around the
oocyte a few hours before ovulation and plays vital roles in oocyte biology. Here, we …
oocyte a few hours before ovulation and plays vital roles in oocyte biology. Here, we …