Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

CFTR is a cAMP-activated chloride and bicarbonate channel that is critical for lung
homeostasis. Decreases in CFTR expression have dire consequences in cystic fibrosis (CF) …

Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung
disease, characterized by recurrent and chronic bacterial infection and inflammation since …

A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil
infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The …

A large number of correctors have been identified that can partially repair defects in folding,
stability and trafficking of CFTR processing mutants that cause cystic fibrosis (CF). The best …

Cystic fibrosis (CF), the most common, life-threatening monogenetic disease in Caucasians,
is caused by mutations in the CFTR gene, encoding a cAMP-and cGMP-regulated epithelial …

Cystic fibrosis (CF) is an inherited disorder caused by mutations in the gene encoding for the
cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ATP-gated chloride …

Chronic infection and inflammation are the primary causes of declining lung function in
Cystic Fibrosis (CF) patients. ORKAMBI®(Lumacaftor-Ivacaftor) is an approved combination …

The synthetic antimicrobial peptide SET-M33 has strong activity against bacterial infections
caused by Gram-negative bacteria. It is currently in preclinical development as a new drug to …

Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation
is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions …