The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator
undermine many host defense systems by inhibiting the function of airway-surface liquid …

S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent
infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance …

Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection,
inflammation, and mucus accumulation to progressively destroy the lungs. Our previous …

The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …

Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …

Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …