State-of-the-art materials for ultrasound-triggered drug delivery
Ultrasound is a unique and exciting theranostic modality that can be used to track drug
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …
carriers, trigger drug release and improve drug deposition with high spatial precision. In this …
Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer
N Rapoport - Wiley Interdisciplinary Reviews: Nanomedicine …, 2012 - Wiley Online Library
This review focuses on phase‐shift perfluorocarbon nanoemulsions whose action depends
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …
Stimulation of bone repair with ultrasound: a review of the possible mechanic effects
In vivo and in vitro studies have demonstrated the positive role that ultrasound can play in
the enhancement of fracture healing or in the reactivation of a failed healing process. We …
the enhancement of fracture healing or in the reactivation of a failed healing process. We …
Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons
PS Sheeran, SH Luois, LB Mullin, TO Matsunaga… - Biomaterials, 2012 - Elsevier
Recently, an interest has developed in designing biomaterials for medical ultrasonics that
can provide the acoustic activity of microbubbles, but with improved stability in vivo and a …
can provide the acoustic activity of microbubbles, but with improved stability in vivo and a …
Phase-change contrast agents for imaging and therapy
PS Sheeran, PA Dayton - Current pharmaceutical design, 2012 - ingentaconnect.com
Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …
Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging
PS Sheeran, VP Wong, S Luois, RJ McFarland… - Ultrasound in medicine …, 2011 - Elsevier
Currently available microbubbles used for ultrasound imaging and therapeutics are limited
to intravascular space due to their size distribution in the micron range. Phase-change …
to intravascular space due to their size distribution in the micron range. Phase-change …
Characterization of submicron phase-change perfluorocarbon droplets for extravascular ultrasound imaging of cancer
Because many tumors possess blood vessels permeable to particles with diameters of 200
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …
[HTML][HTML] Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions
The development of phase-shift droplets has broadened the scope of ultrasound-based
biomedical applications. When subjected to sufficient acoustic pressures, the …
biomedical applications. When subjected to sufficient acoustic pressures, the …
Ultrasound induced cancer immunotherapy
J Unga, M Hashida - Advanced drug delivery reviews, 2014 - Elsevier
Recently, the use of ultrasound (US) has been shown to have potential in cancer
immunotherapy. High intensity focused US destruction of tumors may lead to immunity …
immunotherapy. High intensity focused US destruction of tumors may lead to immunity …
Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies
O Couture, J Foley, NF Kassell, B Larrat… - Translational Cancer …, 2014 - tcr.amegroups.org
Therapeutic ultrasound has been used to thermally ablate solid tumors since the 90s, and a
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …