Engineering the next generation of cell-based therapeutics
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …
intractable diseases through uniquely powerful modes of action. Despite notable recent …
The evolution of synthetic receptor systems
Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …
environments. Over the past two decades, synthetic biologists have repurposed physical …
Multidimensional control of therapeutic human cell function with synthetic gene circuits
Synthetic gene circuits that precisely control human cell function could expand the
capabilities of gene-and cell-based therapies. However, platforms for developing circuits in …
capabilities of gene-and cell-based therapies. However, platforms for developing circuits in …
Customizing cellular signal processing by synthetic multi-level regulatory circuits
As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …
systems must be customized to meet practical demands. Towards this mission, novel …
Synthetic multistability in mammalian cells
R Zhu, JM del Rio-Salgado, J Garcia-Ojalvo… - Science, 2022 - science.org
In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …
distinct, mitotically heritable states through the property of multistability. Designing synthetic …
A cybergenetic framework for engineering intein-mediated integral feedback control systems
The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …
An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells
Synthetic biology has the potential to bring forth advanced genetic devices for applications
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …
in healthcare and biotechnology. However, accurately predicting the behavior of engineered …
[HTML][HTML] Context-aware synthetic biology by controller design: Engineering the mammalian cell
The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …
Programmable synthetic receptors: the next-generation of cell and gene therapies
F Teng, T Cui, L Zhou, Q Gao, Q Zhou… - Signal Transduction and …, 2024 - nature.com
Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …
diseases. However, concerns over the safety and efficacy require to be further addressed in …
Synthetic transcription factor engineering for cell and gene therapy
B Bhatt, P García-Díaz, GW Foight - Trends in Biotechnology, 2023 - cell.com
Synthetic transcription factors (synTFs) that control beneficial transgene expression are an
important method to increase the safety and efficacy of cell and gene therapy. Reliance on …
important method to increase the safety and efficacy of cell and gene therapy. Reliance on …