Coronaviruses (CoV) are enveloped, plus-strand RNA viruses that have the largest known
RNA genomes and infect birds and mammals, causing various diseases. Human …

The prototypic response to viral infection involves the recognition of pathogen-associated
molecular patterns (PAMPs) by pattern recognition receptors (PRRs), leading to the …

Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.
Studies of motif-mediated interactions therefore provide insight into virus-host …

Reovirus infection requires the concerted action of viral and host factors to promote cell
entry. After interaction of reovirus attachment protein σ1 with cell-surface carbohydrates and …

Piscine orthoreovirus (PRV) is associated with heart-and skeletal muscle inflammation
(HSMI) of farmed Atlantic salmon (Salmo salar). We have performed detailed sequence …

Upon viral infection, an arms-race between the cellular intrinsic innate immune system and
viral replication is established. To win this race, viruses have established multiple strategies …

Within infected host cells, mammalian orthoreovirus (MRV) forms viral factories (VFs), which
are sites of viral transcription, translation, assembly, and replication. The MRV nonstructural …

Although it is well established that hepatitis C virus (HCV) entry into hepatocytes depends
on clathrin-mediated endocytosis, the possible roles of clathrin in other steps of the viral …

We tested a strategy for engineering recombinant mammalian reoviruses (rMRVs) to
express exogenous polypeptides. One important feature is that these rMRVs are designed to …

Mammalian reovirus viral factories (VFs) form filamentous or globular structures depending
on the viral strain. In this study, we attempt to characterize the dynamics of both filamentous …