Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2
pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins …

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly
pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this …

The lectin pathway of complement activation is an important component of the innate
immune defense. The initiation complexes of the lectin pathway consist of a recognition …

In the context of immunity, pattern recognition is the art of discriminating friend from foe and
innocuous from noxious. The basis of discrimination is the existence of evolutionarily …

Mannan-binding lectin (MBL), L-ficolin, M-ficolin and H-ficolin are all complement activating
soluble pattern recognition molecules with recognition domains linked to collagen-like …

Understanding the structural organisation and mode of action of the initiating complex of the
classical pathway of complement activation (C1) has been a central goal in complement …

Recent studies have revealed profound developmental consequences of mutations in genes
encoding proteins of the lectin pathway of complement activation, a central component of the …

To initiate the lectin pathway of complement pattern recognition molecules bind to surface-
linked carbohydrates or acetyl groups on pathogens or damaged self-tissue. This leads to …