Membrane proteins remain challenging targets for structural biologists, despite recent
technical developments regarding sample preparation and structure determination. We …

The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Transmembrane proteins within biological membranes exhibit varieties of important
functions that are vital for many cellular activities, and the development of their synthetic …

Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and
the production of bioactive secondary metabolites in filamentous fungi. Phosphate …

As a member of the transient receptor potential (TRP) channels superfamily, the TRPV1
channel undergoes a closed-to-open gating transition in response to various physical and …

The activity of thermo-transient receptor potential (TRP) channels is highly dependent on
temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In …

Highlights The intracellular calcium content plays a key role in the expression of genes
involved in the biosynthesis and secretion of fungal metabolites. The cytosolic calcium …

A distinct set of channels and transporters regulates the ion fluxes across the lysosomal
membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is …

As a prototype cellular sensor, the TRPV1 cation channel undergoes a closed-to-open
gating transition in response to various physical and chemical stimuli including noxious …