The role of NO/sGC/cGMP/PKG signaling pathway in regulation of platelet function
S Gambaryan - Cells, 2022 - mdpi.com
Circulating blood platelets are controlled by stimulatory and inhibitory factors, and a tightly
regulated equilibrium between these two opposing processes is essential for normal platelet …
regulated equilibrium between these two opposing processes is essential for normal platelet …
[HTML][HTML] Inherited thrombocytopenias: history, advances and perspectives
AT Nurden, P Nurden - Haematologica, 2020 - ncbi.nlm.nih.gov
Over the last 100 years the role of platelets in hemostatic events and their production by
megakaryocytes have gradually been defined. Progressively, thrombocytopenia was …
megakaryocytes have gradually been defined. Progressively, thrombocytopenia was …
Inherited thrombocytopenia: update on genes and genetic variants which may be associated with bleeding
Inherited thrombocytopenia (IT) is comprised of a group of hereditary disorders
characterized by a reduced platelet count as the main feature, and often with abnormal …
characterized by a reduced platelet count as the main feature, and often with abnormal …
Screening and diagnosis of inherited platelet disorders
A Bourguignon, S Tasneem… - Critical Reviews in Clinical …, 2022 - Taylor & Francis
Inherited platelet disorders are important conditions that often manifest with bleeding. These
disorders have heterogeneous underlying pathologies. Some are syndromic disorders with …
disorders have heterogeneous underlying pathologies. Some are syndromic disorders with …
IL-22 regulates MASTL expression in intestinal epithelial cells
Microtubule-associated serine-threonine kinase-like (MASTL) has recently been identified
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …
C3G contributes to platelet activation and aggregation by regulating major signaling pathways
S Gutiérrez-Herrero, C Fernández-Infante… - Signal transduction and …, 2020 - nature.com
Abstract C3G is a GEF (guanine nucleotide exchange factor) for Rap GTPases, among
which the isoform Rap1b is an essential protein in platelet biology. Using transgenic mouse …
which the isoform Rap1b is an essential protein in platelet biology. Using transgenic mouse …
The oncogenic functions of MASTL kinase
MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate
phosphorylation is correctly maintained. It achieves this through the phosphorylation of …
phosphorylation is correctly maintained. It achieves this through the phosphorylation of …
The cell cycle checkpoint system MAST (L)-ENSA/ARPP19-PP2A is targeted by cAMP/PKA and cGMP/PKG in anucleate human platelets
The cell cycle is controlled by microtubule-associated serine/threonine kinase-like (MASTL),
which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α …
which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α …
MASTL promotes cell contractility and motility through kinase-independent signaling
ME Taskinen, E Närvä, JRW Conway… - Journal of Cell …, 2020 - rupress.org
Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-
accelerating kinase with emerging roles in cancer progression. However, possible cell cycle …
accelerating kinase with emerging roles in cancer progression. However, possible cell cycle …
Comparison of the central human and mouse platelet signaling cascade by systems biological analysis
J Balkenhol, KV Kaltdorf, E Mammadova-Bach… - BMC genomics, 2020 - Springer
Background Understanding the molecular mechanisms of platelet activation and
aggregation is of high interest for basic and clinical hemostasis and thrombosis research …
aggregation is of high interest for basic and clinical hemostasis and thrombosis research …